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Oncology, Radiation Therapy

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Leukemia in children and adults

Special oncology - educational material

Acute leukemia - model of ethiology, symptoms, laboratory, bone changes, bone marrow puncture, molecular aberrations, immunophenotypes, cytogenetics, incidence, protocols, treatment, outcome of relapse, ALL, AML, APL, acute leukemia in Down syndrome, treatment side effects, serious adverse events, late effects, CML

Histiocytosis

Author: Jan Starý

Special oncology - educational materials

Langerhans cell histiocytosis (LCH), histiocytosis XEtiology, pathogenesis, diagnosis
granulomas composed of Langerhans cells, macrophages, lymphocytes, eosinophils
LC and lymphocytes produce cytokines (IL-1, IL-2, IL-3, IL-4, IL-6, IFNγ, TNFα), provoking fever, osteolysis etc.
Langerhans cell – APC dendritic cell skin, in LCH activated
CD1a antigen, cytoplasmatic S100 protein, Birbeck granules
Reactive or tumorous disorder?
Clonal proliferative tumorous disorder with variabile clinical manifestation