Leukemia in children and adults
Special oncology - educational material
Acute leukemia - model of ethiology, symptoms, laboratory, bone changes, bone marrow puncture, molecular aberrations, immunophenotypes, cytogenetics, incidence, protocols, treatment, outcome of relapse, ALL, AML, APL, acute leukemia in Down syndrome, treatment side effects, serious adverse events, late effects, CML
Anemia in children and adolescents
Paediatrics II - educational material
Classification of anemias according to the size of red cells, Red Cells Indexes, Development of hemoglobin and erythrocyte volume values since birth into adulthood, POSTNATAL CHANGES OF HEMOGLOBIN, Microcytic anemias, Iron in an organism, Iron absorption, Hepcidin and iron metabolism, Intercellular Iron Transport, Causes of iron deficiency anemia - Inadequate absorption, Insufficient/Inaccessible iron stores, Inborn/acquired errors of iron metabolism
Bone marrow fairule
Peadiatrics II - educational material
Acquired and congenital bone marrow failures, Aplastic anemia, Paroxysmal nocturnal hemoglobinuria, Congenital disorders of all 3 hematopoietic lineages, Fanconi anemia, Dyskeratosis congenita, Shwachman-Diamond syndrom, Amegakaryocytic thrombocytopenia, Isolated failure of erythropoiesis, Diamond-Blackfan anemia, Congenital dyserythropoietic anemia, Isolated failure of granulopoiesis, Isolated failure of megakaryopoiesis
Neutropaenia - paediatrics
Paediatrics - educational material
Development of WBC, Severe chronic neutropenia, Severe congenital neutropenia (Kostmann syndrome), Cyclic neutropenia, Idiopathic neutropenia, Autoimunne neutropenia, Other: SAA, MDS, SCID, isoimmune neonatal neutropenia, HIV, viral hepatitis EBV, parvovirus, chemotherapy, radiation, toxins (bensen), drugs (CHLMF), deficit vitamin B12, folate
Histiocytosis
Special oncology - educational materials
Langerhans cell histiocytosis (LCH), histiocytosis X Etiology, pathogenesis, diagnosis
granulomas composed of Langerhans cells, macrophages, lymphocytes, eosinophils
LC and lymphocytes produce cytokines (IL-1, IL-2, IL-3, IL-4, IL-6, IFNγ, TNFα), provoking fever, osteolysis etc.
Langerhans cell – APC dendritic cell skin, in LCH activated
CD1a antigen, cytoplasmatic S100 protein, Birbeck granules
Reactive or tumorous disorder?
Clonal proliferative tumorous disorder with variabile clinical manifestation
Department of Paediatric Haematology and Oncology
2nd Faculty of Medicine Official Web Site