Department of Paediatric Haematology and Oncology, Charles University, 2nd Medical Faculty, http://kdho.lf2.cuni.cz/

Special oncology - educational material

Acute leukemia - model of ethiology, symptoms, laboratory, bone changes, bone marrow puncture, molecular aberrations, immunophenotypes, cytogenetics, incidence, protocols, treatment, outcome of relapse, ALL, AML, APL, acute leukemia in Down syndrome, treatment side effects, serious adverse events, late effects, CML

Paediatrics II - educational material

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educational material - 5th year, Paediatrics

blood donor, donation of blood, blood products - indication for use, precaution in use, types of products, modification, pretransfusion compatibility testing, measures, safety, clinical surveillance, transfusion reactions                                                                                                                                                                                                                                   

Paediatrics II - educational material

Classification of anemias according to the size of red cells, Red Cells Indexes, Development of  hemoglobin and erythrocyte volume values since birth into adulthood, POSTNATAL CHANGES OF HEMOGLOBIN, Microcytic anemias, Iron in an organism, Iron absorption, Hepcidin and iron metabolism, Intercellular Iron Transport, Causes of iron deficiency anemia - Inadequate absorption, Insufficient/Inaccessible iron stores, Inborn/acquired errors of iron metabolism

Peadiatrics II - educational material

Acquired and congenital bone marrow failures, Aplastic anemia, Paroxysmal nocturnal hemoglobinuria, Congenital disorders of all 3 hematopoietic lineages, Fanconi anemia, Dyskeratosis congenita, Shwachman-Diamond syndrom, Amegakaryocytic thrombocytopenia, Isolated failure of erythropoiesis, Diamond-Blackfan anemia, Congenital dyserythropoietic anemia, Isolated failure of granulopoiesis, Isolated failure of megakaryopoiesis

Paediatrics - educational material

Development of WBC, Severe chronic neutropenia, Severe congenital neutropenia (Kostmann syndrome), Cyclic neutropenia, Idiopathic neutropenia, Autoimunne neutropenia, Other: SAA, MDS, SCID, isoimmune neonatal neutropenia, HIV, viral hepatitis EBV, parvovirus, chemotherapy, radiation, toxins (bensen), drugs (CHLMF), deficit vitamin B12, folate

Special oncology - educational materials

Langerhans cell histiocytosis (LCH), histiocytosis XEtiology, pathogenesis, diagnosis
granulomas composed of Langerhans cells, macrophages, lymphocytes, eosinophils
LC and lymphocytes produce cytokines (IL-1, IL-2, IL-3, IL-4, IL-6, IFNγ, TNFα), provoking fever, osteolysis etc.
Langerhans cell – APC dendritic cell skin, in LCH activated
CD1a antigen, cytoplasmatic S100 protein, Birbeck granules
Reactive or tumorous disorder?
Clonal proliferative tumorous disorder with variabile clinical manifestation

special oncology - educational material

educational material - oncology

educational material - oncology