2.lékařská fakulta
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Special oncology - educational materials

Langerhans cell histiocytosis (LCH), histiocytosis X Etiology, pathogenesis, diagnosis
granulomas composed of Langerhans cells, macrophages, lymphocytes, eosinophils
LC and lymphocytes produce cytokines (IL-1, IL-2, IL-3, IL-4, IL-6, IFNγ, TNFα), provoking fever, osteolysis etc.
Langerhans cell – APC dendritic cell skin, in LCH activated
CD1a antigen, cytoplasmatic S100 protein, Birbeck granules
Reactive or tumorous disorder?
Clonal proliferative tumorous disorder with variabile clinical manifestation

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pdf Histiocytosis Download - HistiocytosisOpen in new window - Histiocytosis 10.9.2013 788.09 KB faculty member Creative Commons License

Keywords: Histiocytosis, pathogenesis, diagnosis

Creative Commons LicenseContribution content is subject to licence Creative Commons Uveďte autora-Neužívejte dílo komerčně-Nezasahujte do díla Attribution 3.0 Czech Republic
author: Jan Starý | organization: Department of Paediatric Haematology and Oncology | published on: 16.6.2010 | last modified on: 10.9.2013
citation: Starý Jan: Histiocytosis. Multimedia support in the education of clinical and health care disciplines :: Portal of 2. Faculty of Medicine [online] 2010-06-16, last modif. 2013-09-10 [cit. 2020-07-16] Available from WWW: <http://mefanet-motol.cuni.cz/articles.php?aid=1133>.

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